Amyloid-Fibril Disruption by Ultrasonic Wave and Infrared Laser Observed by Molecular Dynamics Simulation

Abstract

Non-equilibrium molecular dynamics simulations to destroy amyloid fibrils of amyloid-β peptides by ultrasonic wave and infrared laser irradiation are reviewed. The ultrasonic wave was mimicked by time-varying sinusoidal pressure and infrared laser by pulses of oscillating electric field. Atomic-level dynamical behaviors of amyloid-fibril disruption were observed. The similarities and differences in the amyloid fibril disruption by ultrasonic wave and infrared laser are discussed.