Abstract
Supramolecular chemistry is the study of the structure and functions of the supramolecules that result from binding substrates to molecular receptors [1a]. In this field, many chemists have been challenging either to reproduce highly sophisticated reactions occuring in living bodies, or to construct intelligent molecular systems with refined functions. This review describes representative examples of applications of high pressure to supramolecular chemistry, including the results of our efforts to construct certain supramolecules at high pressures.