Establishment of a cross-sectional HBOC database in our hospital

Abstract

　At our hospital, BRCA1/2 genetic testing is performed in each department, and when a pathogenic germline variant is detected, the physician in charge refers the patient to genetic counseling (GC). To ensure the quality of Hereditary breast and ovarian cancer (HBOC) care, there is a need for a system that can comprehensively monitor and manage factors such as the number of tests conducted, attendance at GC, and the implementation status of risk-reducing surgeries across departments. Recognizing this need, the relevant departments collaborated to establish an HBOC database. This database has enabled the selection of HBOC patients who are eligible for GC and helped certified genetic counselors to effectively remind physicians to refer patients for GC. Additionally, the database has enabled the provision of up-to-date information to individuals carrying a pathogenic germline variant, and has also deepened cooperation among clinicians, clinical geneticists, and genetic counselors, which has in turn improved the quality of HBOC treatment. We believe that the creation and operation of the HBOC database will contribute to the systematization of support for those with hereditary tumors.