The present status of risk-reducing salpingo-oophorectomy (RRSO) for women with hereditary breast and ovarian cancer (HBOC) women at our institution

Abstract

　Objective : This study investigated the clinical background and clinicopathological results of hereditary breast and ovarian cancer (HBOC) women underwent risk-reducing salpingo-oophorectomy (RRSO) at our institution.

Methods : 37 HBOC women who underwent RRSO from January 2018 to December 2023 at the University of Tsukuba Hospital were included. Clinical information was collected retrospectively.

Results : Of 37 patients, 19 (51.4%) had BRCA1, 18 (48.6%) had BRCA2 pathogenic variants. The median age at RRSO is 50 (31-69). 36 patients (97.3%) had medical history of breast cancer. 34 patients (91.9%). After the RRSO, we reviewed 1 patient with serous tubal intraepithelial carcinoma (STIC). In the follow-up period, any patients developed the peritoneal cancer.

Conclusion : The age at RRSO for women with HBOC at our institution was higher than the recommended age. Factors related to the higher age at RRSO included delayed HBOC diagnosis and time to decision before RRSO. Both may be associated with financial burdens.