Clinical assessment of the correlation between organ dysfunction and plasma E-selectin levels in patients with systemic inflammatory response syndrome (SIRS)

Abstract

Objectives: A retrospective observational study was conducted to evaluate whether the plasma level of soluble E-selectin, one of the adhesion molecules, might be related to organ dysfunction in patients with systemic inflammatory response syndrome (SIRS). Methods: The data of 52 patients admitted to the ICU with SIRS and initiated on mechanical ventilation were retrospectively evaluated. Results: The plasma levels of soluble E-selectin determined within 24 hours of admission to the ICU were significantly correlated with the Sequential Organ Failure Assessment (SOFA) scores. Furthermore, the scores for respiratory dysfunction (evaluated by the P/F ratio) in the SOFA scoring system were also significantly correlated with the plasma levels of soluble E-selectin. In relation to respiratory dysfunction, the plasma levels of soluble E-selectin were higher in patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) than in the non-ALI/ARDS patients, and a receiver operating characteristic (ROC) analysis revealed that this parameter might be a specific marker of ALI/ARDS. Conclusions: E-selectin, one of the adhesion molecules, might be closely related to the occurrence of respiratory dysfunction in patients with SIRS.