Abstract
Microaspiration around the cuff and biofilm formation on the surface of the endotracheal tube play important roles in the pathophysiology of ventilator-associated pneumonia (VAP). Several prophylactic interventions, such as adequate cuff pressure control and subglottic secretion drainage, are included in the current guidelines for the prevention of VAP. Additionally, new technologies aimed to suppress fluid leakage around the cuff and biofilm formation on the surface of the endotracheal tube have been investigated. Among them, the improvement of the cuff material and shape, and an antibiotic coating on the endotracheal tube have been successfully reduced the incidence of VAP in clinical trials.
