Endotoxin activity assayの急性腎傷害および持続的腎代替療法における評価

松原 全宏; 井口 竜太; 比留間 孝広; 中村 謙介; 中島 勧; 片桐 大輔; 土井 研人; 野入 英世

doi:10.3918/jsicm.20.235

ORIGINAL ARTICLES

Evaluation of endotoxin activity assay in acute kidney injury and continuous renal replacement therapy

Takehiro Matsubara, Ryouta Inokuchi, Takahiro Hiruma, Kensuke Nakamura, Susumu Nakajima, Daisuke Katagiri, Kent Doi, Eisei Noiri

Author information

Takehiro Matsubara
Emergency and Critical Care Medicine, The University of Tokyo Hospital
Ryouta Inokuchi
Emergency and Critical Care Medicine, The University of Tokyo Hospital
Takahiro Hiruma
Emergency and Critical Care Medicine, The University of Tokyo Hospital
Kensuke Nakamura
Emergency and Critical Care Medicine, The University of Tokyo Hospital
Susumu Nakajima
Emergency and Critical Care Medicine, The University of Tokyo Hospital
Daisuke Katagiri
Nephrology and Endocrinology, Hemodialysis and Apheresis, The University of Tokyo Hospital
Kent Doi
Nephrology and Endocrinology, Hemodialysis and Apheresis, The University of Tokyo Hospital
Eisei Noiri
Nephrology and Endocrinology, Hemodialysis and Apheresis, The University of Tokyo Hospital

Keywords: acute kidney injury, endotoxin, continuous renal replacement therapy, sepsis, endotoxin activity assay

JOURNAL FREE ACCESS

2013 Volume 20 Issue 2 Pages 235-242

DOI https://doi.org/10.3918/jsicm.20.235

Details

Abstract

Background: Endotoxin activity assay (EAA) is an ex vivo diagnostic test for endotoxemia and is based on the biological response of the patient's neutrophils. Reportedly, acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) can induce neutrophil activation. The present study examined whether EAA can detect sepsis in AKI treated by CRRT. Methods: AKI patients who needed CRRT in the intensive care unit were prospectively analyzed. EAA was performed at the initiation of CRRT (0 hr) and 24 hrs and 48 hrs after CRRT. Results: Endotoxin activity (EA) values in the sepsis group were significantly higher than those in the non-sepsis group at 0 hr. No significant increase of EA values was observed after CRRT initiation. Conclusion: EAA can detect sepsis without being influenced by AKI and CRRT.

Corresponding author

Register with J-STAGE for free!