Abstract
Zonisamide is an anticonvulsant. Oligohidrosis is a known side effect of zonisamide treatment in children. However, few studies have reported zonisamide-induced oligohidrosis in adults. We report two cases, each of oligohidrosis and hyperthermia after administration of zonisamide in adult patients with brain trauma. <Case 1> A 21-year-old man was injured in a traffic accident. Treatment with 300 mg/day zonisamide was administered 22 days after the admission. Although, no symptoms of infection were observed, prolonged hyperthermia was noted. The patient became afebrile 3 days after the zonisamide dose was decreased. <Case 2> A 25-year-old man was injured in a traffic accident. Treatment with 300 mg/day zonisamide was administered 3 days after the admission. After drug administration, prolonged hyperthermia was observed. The patient became afebrile 3 days after termination of zonisamide treatment. In adults, zonisamide can induce oligohidrosis and hyperthermia. Thus, the side effects of zonisamide treatment should be considered in the differential diagnosis of hyperthermia.
