Abstract
The usefulness of plasma exchange (PE) for hemolytic uremic syndrome (HUS) by enterohemorrhagic Escherichia coli (EHEC) is unclear. On the other hand, there were no reports of the relationship between central nervous system (CNS) disorder and renal dysfunction. We report three pediatric patients with HUS by EHEC, two patients with PE and one without PE, and their renal dysfunction. The subjects were 3 patients with HUS by EHEC admitted to the ICU. On admission, anuria was noted in all subjects. Continuous hemodiafiltration (CHDF) was started. In 2 patients with CNS disorder, PE was performed for 3 days starting from 9 and 10 days after the onset of digestive symptoms, respectively. In these patients, CNS disorder was not observed on discharge from the ICU. The CHDF period was 9 and 13 days, respectively. It was 36 days in a non-PE-treated patient without CNS disorder.
