Abstract
To evaluate the influence of renal function on serum levels of cardiac markers (cardiac troponin T, cTnT and human heart-type fatty acid-binding protein, H-FABP), we measured these parameters and renal function tests on admission in critically ill patients who did not have cardiac disease or chronic kidney disease. Seventy patients divided into two groups according to the result of whole blood panel test for rapid detection of H-FABP negative group (patients with whole blood panel test for H-FABP of less than cut-off value, n=30) and positive group (greater than cut-off value, n=40). The cTnT was detected in 3 patients (4%) in H-FABP positive group. The serum levels of BUN and creatinine in positive group were significantly higher than those of negative group (BUN: 32.0±27.1mg·dl-1 vs. 12.1±4.1mg·dl-1, P<0.0001; creatinine: 1.7±0.9mg·dl-1 vs. 0.9±0.2mg·dl-1, P<0.0001), and creatinine clearance of positive group was lower than that of negative group (48.4±23.5ml·min-1 vs. 76.7±21.0ml·min-1, P<0.0001). The value of BUN (r=0.429, P<0.0001), creatinine (r=0.693, P<0.0001) and creatinine clearance (r=-0.426, P<0.0001) correlated with the serum level of H-FABP. These results indicate that impairment of renal function may affect the value of H-FABP in critically ill patients.
