Diagnostic significance of serum human hepatocyte growth factor (hHGF) in acute coronary syndrome

Abstract

We measured serum human hepatocyte growth factor (hHGF) in patients with acute myocardial infarction (AMI: n=58), unstable angina (UAP: n=21), and stable effort angina (AP: n=67). Mean value of serum hHGF was 3.42ng·ml^-1 in AMI group and was significantly higher than those of UAP group (0.86ng·ml^-1) or AP group (0.37ng·ml^-1). In AMI group, serum hHGF rose earlier than serum CK. Peak time of serum hHGF values was in 6-12 hours after the onset and that of CK was in 12-24 hours.
There were no significant difference of serum hHGF values between the subgroups of AMI with collateral circulation and without collateral circulation, although collateral subgroup showed higher serum hHGF values than no-collateral subgroup (4.66ng·ml^-1 v. s. 1.82ng·ml^-1). We considered the serum hHGF in acute coronary syndrome to be of diagnostic value.