Abstract
A 24-year-old man attempted suicide by taking 20g of aspirin. Twelve hours after ingestion he admitted to the hospital with complaint of severe nausea and fever. His symptoms included tachycardia, tachypnea, hyperidrosis and severe dehydration which was confirmed by laboratory data. In order to correct dehydration and facilitate salycylate elimination, massive fluid was infused for 48 hours together with furosemide 10mg·hr-1 and intravenous bicarbonate. Although urine volume was maintained, the levels of blood urea nitrogen, creatinine and creatinine kinase were elevated continuously. We induced hemodialysis for acute renal failure caused in part by rhabdomyolysis. Two times of hemodialysis decreased serum salycylate concentration lower than the pharmacokinetically calculated value and improved patient's symptoms. This case study suggests the effectiveness of hemodialysis on high-dose aspirin ingestion.
