Abstract
A 62 year-old woman with rheumatoid arthritis and scleroderma was given transfusion due to anemia. Eleven hours after transfusion, she revealed transfusion-related acute lung injury (TRALI). The origin of TRALI might be an presence of anti- granulocyte antibody in the plasma from her. Glucocortico-steroid therapy could rescue her from acute pulmonary edema. Since the serum concentration of surfactant protein D and KL-6 well reflected her repiratory conditions, these markers might be beneficial to clinical monitoring for TRALI. This paper is the first report suggesting the relationship between TRALI and clinical markers such as SP-D and KL-6, and the case with rheumatoid arthritis and scleroderma following TRALI.
