Abstract
An apparantly nonimmunogenic synthetic compound N, N-dioctadecyl-N', N'-bis (2-hydro-xyethyl) propanediamine (CP-20961) disolved in mineral oil and made into emulsion (10 mg/0.2 ml/rat) induced polyarthritis by single injection in the footpad of Lewis rats. The polyarthritis was almost indistinguishable morphologically from classic adjuvant arthritis induced by Freund's complete adjuvant, a disease generally thought to be the result of a dayed type hypersensitivity reaction to a constituent (s) of the injected tubercle bacilli. The joints demonstrated intense destruction, profound pannus formation, exuberant periostal new bone formation, and large clusters of neutrophils infiltration. The disease induced by alkyldiamine (CP-20961) and that induced by Freund's complete adjuvant followed the same time course and almost identical pattern of development of clinical and histopathological features.
