Abstract
Inflammation in Behçet's syndrome is characterized clinicopathologically by the increase of vascular permeability, the elevated chemotaxis and random mobility of polymorphonuccear leukocytes, and thrombus formation. These findings suggest the possibility that lysosomal enzymes may contribute to the pathogenesis of Behçet's syndrome. The possibility is also supported by the fact that in Behçet's syndrome activities of lysosomal enzymes and protease inhibitors in serum are elevated especially in acute phase. These enzymes are probably released from phagocytic cells, especialy from polymorphonuclear leukocytes. The role of circulating immune complex, lysosomal membrane-labilizing serum factor and accumulation of chemical agent in lysosome has been discussed for abnormal release of lysosomal enzymes.
Colchicine inhibits strongly the mobility of polymorphonuclear leukocytes. It has been administered with satisfactory results, especially on ocular symptoms. Studies of characteristic findings of inflammation in Behçet's syndrome will serve promising roles not only in exploring the pathogenesis but also in establishing the diagnosis and treatment of this syndrome.
