Abstract
The local anti-inflammatory effects and the systemic effects, including the reduction of the thymus weight, of 17α, 21-diacetoxy-2-bromo-6β, 9α-difluoro-11β hydroxy-1, 4-pregnadiene-3, 20-dione (F-2) were compared with those of fluocinolone acetonide and hydrocortisone acetate by granuloma and granuloma pouch methods. Fluocinolone acetonide and hydrocortisone acetate reduced the thymus and adrenal weights and inhibited the body weight gain at the same doses as they inhibited the formation of granuloma or the accumulation of pouch fluid. F-2 showed an intensive loca anti-inflammatory activity with negligible systemic effects at 25-125 times the minimal effective dose.
After the injection of F-2 into the N2-gas pouch formed on the dorsum of rats, the residual level of F-2 at the injection site was mesured. F-2 showed a marked locally residual property and it's residual per cent was about 75% on the 7 th day and 50% on the 30 th day.
