Ensho
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
Increased percentage of peripheral blood activated cytotoxic T cell in patients with acute phase fulminant hepatitis
Yoko Ohira, Yuko Ichinose, Yoshihiro Sato, Masahito Kuroda, Tohru Takagi, Chokichi Hashimoto, Koichi Saito, Tomoe Nishimaki, Takao Morito, Reiji Kasukawa
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Keywords: fulminant hepatitis, activated cytotoxic T cell
JOURNAL FREE ACCESS

1991 Volume 11 Issue 6 Pages 593-594

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Abstract
The subsets of peripheral blood lymphocytes in 3 cases with acute type of the fulminant hepatitis (FH) were studied.
The percentage of Leu 2a+15- cell and Leu 2a+ HLA-DR+ cell in the peripheral blood at the acute stage increased remarkably in death cases due to FH. In survival cases, increase of Leu 2a+15- cell was not noted, while increase of Leu 2a+ HLA-DR+ was noted. The increase of the percentage of these cells was also noted in the acute viral hepatitis type A (AVH), while ratio of Leu 2a+ HLA-DR+ cell/Leo 2a+15- cell was higher in FH than in AVH.
These data suggest that activated cytotoxic T lymphocytes may play a role in the pathogenesis of FH.
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© The Japanese Society of Inflammation and Regeneration
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