Abstract
Ca-antagonists, which are clinically used as antihypertensive and protectant against troubles in coronary and cerebral arteries, are now reported to possess various other actions to ameliorate the inflammatory diseases. We found that dihydropyridinetype Ca-antagonists suppressed carrageenan paw edema of rats and ischemic paw edema of mice. The most effective was nilvadipine which inhibited also O-2 production of rat peritoneal leukocytes stimulated by Ca-ionophore, f-MLP and PMA. This drug is possible to slow down the development of atherosclerosis for which antioxidant character of drug is recently evaluated. Oxidized LDL must be low by antioxidant treatment Nifedipine is reported to enhance the analgestic action of morphine and the survival of rats which received transplantation of liver kept in nisoldipine increased without immunosuppressants.
