Fundamental and clinical study for neutrophilic alkaline phosphatase (NAP)

Abstract

The neutrophilic alkaline phosphatase (NAP) is a well-known marker of the hematological disease. We know the NAP as a clinical phenomenon, however we don't know clearly its function. Then, we studied the measurement of NAP, and assumed its function. In normal volunteer, there is a difference between membranous NAP (we called free activity) and whole cell NAP (we called total activity) . Between male and female, there is a difference. Between smoker and non-smoker, or among the ovulation period, there is a difference, too. But free/total ratio has no differ-ence in each group.