The effects of non-steroidal anti-inflammatory drugs on prostaglandin E₂ and leukotriene B₄ activities in synovial fluid in osteoarthritis; Especially the effects of dual inhibitor

Abstract

The inhibitory influences of indomethacin (IND) and proglumetacin maleate (PGM) on prostaglandin E₂ (PGE₂) and leukotriene B₄ (LTB₄) activities in synovial fluid in osteoarthritis (OA) were investigated. Clinically, no significant difference was observed in final global improvement rate between IND and PGM groups. PGM group showed an improvement higher than IND group in joint effusion. IND showed selective inhibition of PGE₂ formation, but caused a increase in LTB₄ formation. On the other hand, PGM showed a almost same inhibitory effects both on PGE₂ and LTB₄ formation.
These results indicated that PGM, so called dual inhibitor, had a dual inhibitory effects on cyclooxy-genase and lipoxygenase in vivo.