Abstract
The effect of immunotherapeutic agents on influenza virus B/USSR haemagglutinin (B/HA) induced delayed-type hypersensitivity (DTH) in BALB/c mice was investigated. Until now we have studied in this experiment by using influenza virus A/Kumamoto haemagglutinin (A/HA) . In this study, B/HA induced the DTH reaction same as A/HA did. In immune complex type hypersensitivity, mizoribine (MZR) inhibited the footpad swelling but cyclosporine A (CyA) and salicylazosulphapyridine (SASP) had no effect on the reaction. MZR and CyA inhibited DTH reaction but SASP had no effect on the HA induced footpad swelling which was augmented by cyclophosphamide pretreatment. These findings suggest that immunotherapeutic agensts have various effects respectively.
