Inhibitory effects of normal natural killer cells activity with the supernatants of cultured lymphocytes from pediatric patients with nephrotic syndrome

Abstract

Natural killer cells (NK) activity of normal, healthy donors against K 562 cell line were investigated with or without the supernatants of cultured peripheral blood lymphocytes from primary, nephrotic syndrome.
When the effector cells were incubated for three days with the supernatants of cultured PHA-stimulated lymphocytes from both untreated and treated patients, NK activity was significantly inhibited from normal donors.
Consequently, it was suggested that the inhibitory factor on NK activity consisted in the supernatants of cultured lymphocytes from pediatric patients with nephrotic syndrome.