Abstract
The antifungal and antibacterial activity of both anti-ulcer terpens and sofalconein vitrowere studied.
Among them, plaunotol has proved to show the strongest antibacterial and antifungal activity. It exhibits a wide spectrum activity against dermatophytes and Gram positive bacterias. The weakin vitroactivity of sofalcone against dermatophytes and Gram positive bacterias was recognized and also gefarnate revealed the clinically useful MIC values, whereas teprenone didn't indicate antifungal and antibacterial activityin vitro.
Mechanism of fungicidal action is not clear, but present study suggests that surplus C20unit inhibits the transport of several glycoprotein of cytoplasm and/or metabolites of plaunotol having aldehyde may inhibit the growth of various dermaphytes and bacterias. These results indicate that anti-ulcer terpens and sofalcone may be useful for the treatment of superficial fungal infections.
