Ensho
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
Effects of lecithinized superoxide dismutase (PC-SOD) on respiratory resistance induced by Forssman antiserum in guinea pigs
Jiro Hoshino, Akira Ochiai, Rie Igarashi, Yukio Ueno, Toshiaki Nakayama, Hajime Fujii, Yutaka Mizushima
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Keywords: lecithinized superoxide dismutase, Forssman antiserum, respiratory resistance, guinea pigs, neutrophils
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1992 Volume 13 Issue 3 Pages 249-254

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Abstract
We synthesized lecthinized superoxide dismutase (PC-SOD), recombinant human SOD covalently bound to a lecithin derivative. Next, we studied the pharmacological effect of PC-SOD and the mechanism of that.
PC-SOD inhibited the Forssman antiserum-induced respiratory resistance which is known to induce via actions of O2- at a dose of 100-1, 000 U/kg, whereas unmodified SOD did not.
PC-SOD was more effective at 2.8 fold in inhibiting the superoxide generation of neutrophils than unmodified SOD. Superoxide generation of neutrophils washed after incubation with PC-SOD for 1 hr was inhibited but not with unmodified SOD.
These data suggest that PC-SOD protects lung injury by Forssman antiserum in guinea pigs by binding to neutrophils. PC-SOD would be expected as a useful drug delivery system preparation for SOD.
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© The Japanese Society of Inflammation and Regeneration
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