Abstract
We identified transfomation-associated cell surface antigens (TAAs) that are expressed on a W31 H-rasoncogene trasformant of WFB rat fibroblast. One of TAAs, defined by mAb067, showed the enhanced expression by physicochemical stressors, and was supposed to be 70 heat shock cognate protein (hsc) itself. It was also shown that this antigen may be a target for CD4-CD8- double negative T cell (DNT), since mAb067 completely blocks the cytotoxicity of DNT against W31.
These data strongly suggest that 70 hsc is a tumor antigen, and is a potential target for the host's tumor immunity. The capability of antigenic peptide presentation of 70 hsc was discussed.
