Abstract
Deterpens (plaunotol, gefarnate and teprenone) and isoprenyl chalcone derivatives of sofalcone have been extensively employed as a gastric protective agents. The role of these drugs in cytoprotec-tion have been reported, e. g. mucous secretion, macromolecular synthesis, gastric blood flow, bicarbonate secretion and newly formed capillaries and granulation tissue. Furthermore, it is recently indicated that these gastric protective agents promote increase of the migration of fibroblast and epithelial cells. Accordingly, we investigated the accelerating effect of topical preparation of gastric protective agents on healing of ducubitus and skin ulcers caused by vasculitis. Each topical preparation contained same dosage as orally administration dosage and was once a daily administered to ulcerative lesion.
In 20 cases of patients with intractable decubitus, the wound area was significantly reduced within 1 week and re-epithelization of the ulcer edge and the increase of granulation tissue were also observed in 2 weeks after treatment. Healing acceleration rate by these drugs were about the same. In cases of patients with skin ulcers, healing acceleration was also comfirmed.
These results suggest that topical preparation of gastric protective agents are useful for the treatment of wound healing.
