Abstract
The present study was undertaken to clarify the changes of bone metabolism of adjuvant-induced arthritis rats (AA) . After adjuvant inoculation to rats, urinary deoxypiridinoline content was gradually increased with developing AA. The third lumbar vertebra (L3) was used for determination of morphological change on 28 days after adjuvant inoculation. The trabecular bone number of the L3 vertebra significantly decreased in comparison with the control group of the same age. The study has shown that AA has a pronounced effect on vertebral bone mass and quality with collagen destruction.
