Ensho
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
Effect of azelastine on granulocyte-endothelial cell adhesive reactions induced by PAF
Norimasa Yoshida, Toshikazu Yoshikawa, Shoji Iinuma, Yasunari Nakamura, Masahiro Arai, Kiichi Matsuyama, Motoharu Kondo
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Keywords: azelastine, granulocyte, adhesion molecule
JOURNAL FREE ACCESS

1994 Volume 14 Issue 6 Pages 527-529

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Abstract
Effect of azelastine, an anti-allergic compound, on granulocyte-endothelial cell adhesive reactions induced by PAF was investigated using human granulocytes and human umbilical vein endothelial cells. Azelastine inhibited surface expression of CD18 on granulocytes induced by PAF. In addition, azelastine reduced CD18-dependent granulocyte adherence to endothelial cells elicited by PAF.
These results indicate that azelastine has an anti-inflammatory action through inhibiting granulocyte-endothelial cell interactions at inflammatory site.
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© The Japanese Society of Inflammation and Regeneration
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