Abstract
Concentrations of diclofenac in serum and tissues were studied after single oral administration of Voltaren SR capsule in patients with rheumatoid arthritis.
Samples of blood, synovial fluid, synovial membrane, fat and muscle tissues were taken 6 hours or f hours after Voltaren SR administration.
(1) The concentration of diclofenac in the synovial fluid was higher than that of the serum.
(2) The higher concentration of diclofenac in the synovial fluid compared to that of serum lasted for at least 12 hours after administration.
(3) The concentration of diclofenac in the synovial membrane was higher than that in fat and muscle tissues.
These results show that Voltaren. SR capsule has a good distribution to the synovial membrane and synovial fluid, and that it remains there for at least 12 hours.
