Abstract
Masugi nephritis of WKY rats, that is characterized with the early infiltration of CD8 positive lymphocytes and monocytes/macrophages, developed severe proliferative glomerulonephritis with crescent formation. In this model, the expression of ICAM-1 and the infiltration of LFA-1 positive cells were increased in the glomeruli. The blocking studies of CD8, ICAM-1, LFA-1 and MCP-1 in this model were effective for protection of proteinuria and glomerular injury. From these data, cell surface molecules such as adhesion molecules may play important roles in the glomerulonephritis.
