Abstract
Effects of salazosulfapyridine (SASP) and bucillamine (Bc), as disease-modifying antirheumatic drugs (DMARDs), on an active Arthus reaction and a delayed-type hypersensitivity (DTH) response were studied. SASP and Bc significantly suppressed the active Arthus reaction and DTH response. SASP and Bc also increased some cytokines in the DTH mice serum, such as interferon (IFN) -γ, interleukin (IL) -4, and IL-10.
These results suggest that SASP and Bc activate all types of T cells, especially Th0 and Th2 involved in type IV (delayed-type) hypersensitivity, and also suppress type III hypersensitivity activated with immune complex.
