Abstract
Concentration of Indometacin farnesil (IMF), indomethacin (IND) transformed from IMF in serum and synovial fluid were studied after single oral administration of Infree® capsule in patients with rheumatoid arthritis (RA) . Samples of blood, synovial fluid were taken 3 hours, 6 hours, 9 hours and 12 hours after Infree® administration.
1. The maximam concentration of IMF, IND transformed IMF in serum and synovial fluid were obtained at 9 hours after Infree® administration.
2. The ratio of IND/IMF in synovial fluid is constant and higher level than that of IND/IMF in serum. The ratio of IND/IMF in serum is lowered each sampling hours.
These results suggested that Infree® capsule has a constant analgesic/antiinflammatory effect by a good intra-articular transformation of IMF in inflammatory joints of RA patients.
