Abstract
The tumor antigenic peptides of human melanomas have been determined, and applied in the clinical trials. It is also important to investigate the biochemical process for producing these antigenic peptides in the cells. In this report, we suggested that 70 kDa heat shock protein (hsp 70) makes physical complex with TAP molecules. Futhermore, hsp 70 could play an important role to feed HLA-A2-restricetd melanoma tyrosinase antigenic peptides into ER via TAP molecules.
