Abstract
The effect of Sairei-to on radiation induced stomatitis was studied in vitro using human oral epithelial cells and compared with that of Oren-to. Sairei-to (30-300 μg/ml) suppressed both the decrease in adherent cell number after irradiation at 8 Gy and the decrease in cell proliferation after irradiation at 4 Gy in a dose-dependent manner. Without irradiation, however, the drug did not affect the number of adherent cells or the ability of cell proliferation. Although Oren-to (10-100 μg/ml) also suppressed the decrease in adherent cell number after irradiation in a dose-dependent manner, cell proliferative ability was suppressed (100 μg/ml) irrespective of the presence or absence of irradiation. It is suggested that Sairei-to suppresses radiation induced injuries in oral mucosal cells without affecting normal cell function.
