Spleen cells of beige C57BL mice or those of normal C57BL mice were injected intravenously into sublethally irradiated F1 hybrid mice (C57BL×CBA) .Recipient receiving plecn cell of beige mice survived longer than those receiving splecn cells of normal mice. The present result suggests that in beige mice effetor cells of GVH reaction (mainly T-lymphocytes) may have functional impalrments, as do neutrophils, platclets, and natural killer cells.
