Abstract
The prostaglandin field has advanced rapidly during past several years, and there is a rapidly isncreasing interest in the clinical significance and therapeutic use of prostaglanding for many diseases. The object of this paper is to review the present status of knowledge on the physiological roles, clinical significance and therapeutic uses of prostaglandins.
An outline is as follows :
(1) Nomenclature and chemistry of Prostaglandins (PGs) .
(2) Ubiquity of PGs.
(3) PG metabolism (arachidonic cascade) .
(4) Biologic activiteis and physiological roles of PGs.
a. Central nervous system.
b. Endocrine system.
c. Respiratory system.
d. Cardio-vascular system.
e. Hemostatic system.
f. Digestive system.
g. Renal and reproductive system.
h. eye.
(5) Clinical implication of PGs.
A. Platelet and vascular wall.
B. Renin-angiotensin system.
C. Kallikrein-kinin sytem.
D. Salt and water homeostasis.
(6) Clinical applications of PGs and its analogues.
(1) Gynecologic (2) Digestive (3) Cardio-vascular (4) Peripheral vascular ischemia and thromboembolism (5) Respiratory (6) Extracorporeal circulation (7) Ohters
