Effects of CCA (Disodium 4-chloro-2, 2'-iminodibenzoate) on the biological activities of both lymphocytes and macrophages were investigated

Abstract

In the in vitro studies of murine lymphocytes, CCA showed a tendency to increase the viability of spleen cells and an activity to enhance the mitogenic responses of those cells by LPS, B-mitogen. Enhancing effects of CCA on T-mitogen-induced lymphocytes reaction have also been reported in other papers. These results were considered in connection with a phenomenon that CCA increased the RNA polymerase activity of nucleus from rat lymphnode cells. CCA also enhanced thein vivo mitogenic reaction by Con A. CCA was not mytogenic by itself.
As for the activities of macrophages, CCA did not almost show any effects inin vitrostudies while it did in the carbon clearance test using both normal and tumor-bearing animals.