Abstract
The effect of pranoprofen (PPF), indomethacin (IM) and acetylsalicylic acid (ASA) on acute and chronic inflammation, inflammatory pain and gastro-intestinal organ in mice was investigated. The inhibitory effect of PPF on carrageenin- or concanavalin A-induced paw edema, phenylquinone writhing and cotton pellet granuloma formation was as potent as that of IM and more active than that of ASA. In contrast, PPF was about 15 times less active than IM in the production of gastric ulcers in mice. Furthermore, PPF was less active than IM in the inhibition of stomach prostaglandins synthesis and arachidonic acid-induced diarrhea in mice. These results suggest that the less potent activity in inhibiting the gastro-intestinal prostaglandins synthesis of PPF with the potent anti-inflammatory activity contributes to its weak ulcerative effect in mice.
