Ensho
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
SOD activity, NOx, SH level in wobbler mice
Akira Ochiai, Rie Igarashi, Mitsuko Takenaga, Jiro Hoshino, Ken Ikeda, Sadatomo Shimojo, Yutaka Mizushima
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Keywords: wobbler mouse, motoneuron disease, oxidative stress
JOURNAL FREE ACCESS

1999 Volume 20 Issue 1 Pages 57-63

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Abstract
We measured SOD activity, NOx, and free SH level in wobbler mice. Their NOx levels in both brain and spinal cord were significantly higher than those in healthy littermates. In addition, the SOD activity in both brain and spinal cord was lower with a significant difference. Furthermore, it was found that the free SH level in their brain was also lower. These results suggest that free radical might play some role of the motoneuron degeneration in wobbler mice.
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© The Japanese Society of Inflammation and Regeneration
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