Abstract
Whether the apheresis have an anti-inflammatory effect on adjuvant arthritis rats was investigated. The apheresis with Gossypium barbadense cotton and polysulfon filters were done 4 days after immunization with complete adjuvant. Blood was drawn continuously from the tail's artery and introduced into the syringe which contained the filter, and returned to the tail's artery. Three milliliter of whole blood was processed in one time and it was repeated 5 times. In total, 15 ml of whole blood was processed. In laboratory values, WBC from apheresis group showed a higher value level than those from control group, though leukapheresis removed substantial leukocytes. Hemoglobin, hematocrit, platelets and RBC were lower level at 21 days after immunization. The apheresis with Gossypium barbadense cotton showed marked inhibition of swelling and bone destruction in hind legs in rats, and the apheresis with bio-compatible filter, polysulfon also showed marked inhibition of swelling.
