Intra-articular therapy by a topical cortisteroid halopredone acetate in rheumatoid arthritis

Abstract

We evaluated halopredone acetate in basic and clinical aspects. Halopredone acetate is a highly topical corticosteroid. When it is used for intraarticular injections, the effects last longer than any other steroids which have been used, and it has less general effects. We applied halopredone acetate for RA and OA patients. For RA patients, mean dose for a wrist is 12.5 mg and that for a knee is 25 mg. About 90% cases showed effectiveness and in about 45% cases the duration of effect is longer than 4 weeks. More than half cases of OA showed also improvements.