Abstract
Anti-inflam-matory mechanism of butyl flufenamate (HF-264) was studied by various analysis. HF-264 did not inhibited the heat denaturation of bovine serum albumin, whereas flufenamic acid showed a marked inhibition on it. HF-264 and flufenamic acid prevented the dog erythrocytes from heat induced lysis, and inhibited the production of superoxide anion in macrophages. HF-264 inhibited the synthesis of prostaglandin E1, but its inhibition of HF-264 on it was more weaker than that of flufenamic acid. From the above results, it is suggested that some part of potent anti-inflammatory action of HF-264 is the results of the interaction of HF-264 with biomembrane, as membrane stabilization and inhibition of superoxide anion production.
