Abstract
Concomitant effects of CCA with ketoprofen or prednisolone were investigated in the preventive and curative experiments of rat adjuvant arthritis, respectively.
(1) Inhibitory effects of CCA administered with the above each drug on the swelling of rat kind legs were found to be rather weak or almost negative in most cases.
(2) Administration of CCA and ketoprofen concomitantly enhanced the improving effect of each drug on the pathological changes of hemogram (percent increase in neutrophils counts and perceut decrease in lymphocytes counts) in both the prophylactic and curative experients.
(3) Similar improving effects on both the changes of lymphocytes counts in blood and the decrease of albumin/globulin ratio in the serum were shown in the therapeutic experiments treated by CCA and prednisolone.
(4) Concomitant use of CCA and ketoprofen suppressed the increase of tissue weights in adrenals and iliac lymph nodes (treated site) in the therapeutic experients.
