Abstract
Lobenzarit disodium (CCA) showing an electron donating and an anti-oxidative activity was synthesized from the aspect of quantum chemistry using simple LCAO MO method of π electrons in our research laboratories. CCA showed a quenching action against active oxygen-induced weak chemiluminescence. CCA and also levamisole scavenged hydroxyl radicals in the Udenfriend system. From the above-mentioned results, CCA was examined in the model of acute fatty liver of ethanol-treated rats in comparison with DPPD, a famous anti-oxidant. They inhibited the onset of this disease. It would be worthwhile to investigate if CCA affects immune responses or not, because of a reason that immunopotentiators and -modulators such as vitamin A, vitamin E or levamisole also have anti-oxidative and/or radical scavenging actions.
