Abstract
Effects of methyl-B12 on the inflammation induced by CdCl2 in the testis of rats, in which a remarkable increase of oxidative reaction was observed, were investigated. The results are summarized as follows: 1) Serum enzyme activities, i.e., Al-p, LDH, GOT, GPT, did not show any change by the premedication of methyl-B12. 2) Hemorrhage, the damage of blood vessel epithelia and the migration of wondering cells in the testis were reduced markedly by the premedication of methyl-B12. 3) The increase of Ca contents in the rat testis induced by CdCl2 was also supressed significantly by the premedication of methyl-B12. These suggest that methyl-B12 has anti-inflammatory effect against the hemorrhagic inflammation in the testis of rat administered CdCl2.
