Abstract
The effect of a Ca2+ -antagonist (Verapamil) on inflammation caused with CdCl2 (5.0mg/kg) was determined in rat's testis. (1) Concomitant administration of CdCl2 and Verapamil inhibited testicular hemorrhage and an elevation in tissue level of lipid peroxide in the testis. (2) When rats were administered with CdCl2 alone, the content of phospholipids in the testis was decreased, while the content of free fatty acids in the testis was increased, whereas these changes were restored to normal after concomitant administration of Verapamil. (3) When rats were administered with CdCl2 alone, the content of Ca in the testis was significantly increased, while the levels of Mg and K were decreased. These changes were also restored toward normal after concomitant administration of Verapamil. These results suggest that calcium plays an important role in the development of inflammation in the rat testis following the administration of CdCl2.
