Abstract
Plasma levels of thiol proteinase inhibitor and kininogen were determined in rat following the injection of Freund's complete adjuvant into hind-paw. Thiol proteinase inhibitor in plasma increased in the same profile with plasma kininogen levels as well as paw swelling. Either thiol proteinase inhibitor or kininogen in normal and adjuvant-treated rat plasma completely adsorbed on columns with ligands of anti-T-kininogen IgG and S-carboxymethylated papain. These results indicate that thiol proteinase inhibitor elevated in the inflammatory condition attributes to kininogen, especially T-kininogen.
