Study of antigen presenting cells—Age-Dependent Loss of antigen presenting ability in New Zealand black and white (NZB × NZW) F₁ mice and the effect of indomethacin—

Abstract

NZB×NZW F₁ hybrid (B/W F₁) mice have been extensively investigated as model animals for resembling human systemic lupus erythematosus. Some reports suggested, that the aging of B/W F₁ mice provided influences to the immune response and the function of macrophage in B/W F₁.
In the present investigation, we studied on antigen presenting ability of SACs (spleen adherent cells), epidermal cells, Kupffer cells, and alveolar macrophages from B/W F₁ mice in various ages. Aging of these mice decreased antigen presenting ability on SACs, epidermal cells, and alveolar macrophages, but not Kupffer cells. And the response of antigen presening abilities in both B/W F₁ and B₆×DBAF₁ hybrid (B/D F₁) mice were decreased when indomethacin administrated.