Abstract
An experimental liver injury was produced in mice by injection of a sub-hepatotosic dose of anti-basic liver protein (BLP) antibody after immunization of rabbit IgG (RGG) . Strain DBA/2 mice indicated the highest susceptability to the disease. Typical histopathological changes in the liver were submassive hepatocellular necrosis and infiltration of granulocytes and lymphocytes into the portal tract and sinusoid in necrosis lesion. Administration of either prednisolone (10 and 20mg/kg), cyclophosphamide (5 and 10mg/kg) or cianidanol (500 and 1000mg/kg) for 10 days prior to injection of anti-BLP antibody suppressed development of liver injury. These results suggest that the experimental liver injury model in DBA/2 mice is useful for immunopharmacological studies of liver diseases.
