Effect of Juzentaihoto on the anti-SRBC response in mice

Abstract

In order to disclose the effect of “KANPO-YAKU” on immune responses, we investigated the induction of anti-SRBC response (PFC assay) in the spleen cells of BDF1 female mice which received Tsumura-Juzentaihoto (TJ-48) . TJ-48 induced an augmentation of anti-SRBC response by oral administration once a day for 7 consecutive days in a dose dependent manner. The maximum induction of anti-SRBC response was seen by 7 days-administration of TJ-48 (2 g/kg/day) and no further increase was obtained by longer treatment. After withdrawing TJ-48, the augmentation of anti-SRBC response was maintained for 3 days and disappeared by 7 days after the withdrawal. The anti-SRBC response was enhanced whether immunization with SRBC was done in vivo or in vitro.